10-K Filing

NATERA, INC. CIK: 1604821 FY 2021

Filing Information

Form Type	10-K
Accession Number	`0001558370-22-002022`
Period End Date	20211231
Filing Date	20220225
Fiscal Year	2021
Fiscal Period	FY
XBRL Instance	ntra-20211231x10k_htm.xml

Filing Contents

This filing contains the following financial statements:

Balance Sheet 75 Income Statement 50 Cash Flow Statement 117 Stockholders Equity 43

Balance Sheet 75 line items

Line Item	Tag	Value	Unit	Period
Allowances on accounts receivable	`AllowanceForDoubtfulAccountsReceivableCurrent`	$3.08M	USD	Point-in-time
Allowances on accounts receivable	`AllowanceForDoubtfulAccountsReceivableCurrent`	$2.43M	USD	Point-in-time
Common stock, par value (in dollars per share)	`CommonStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Common stock, par value (in dollars per share)	`CommonStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Common stock, shares authorized	`CommonStockSharesAuthorized`	750.00M	shares	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$48.67M	USD	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$84.39M	USD	Point-in-time
Common stock, shares authorized	`CommonStockSharesAuthorized`	750.00M	shares	Point-in-time
Common stock, shares issued	`CommonStockSharesIssued`	5.71M	shares	Point-in-time
Restricted cash	`RestrictedCashAndCashEquivalentsAtCarryingValue`	$187.00K	USD	Point-in-time
Common stock, shares issued	`CommonStockSharesIssued`	86.22M	shares	Point-in-time
Common stock, shares issued	`CommonStockSharesIssued`	95.14M	shares	Point-in-time
Common stock, shares issued	`CommonStockSharesIssued`	4.79M	shares	Point-in-time
Common stock, shares issued	`CommonStockSharesIssued`	5.26M	shares	Point-in-time
Common stock, shares issued	`CommonStockSharesIssued`	5.17M	shares	Point-in-time
Restricted cash	`RestrictedCashAndCashEquivalentsAtCarryingValue`	$228.00K	USD	Point-in-time
Common stock, shares outstanding	`CommonStockSharesOutstanding`	86.22M	shares	Point-in-time
Short-term investments	`MarketableSecuritiesCurrent`	$829.90M	USD	Point-in-time
Short-term investments	`MarketableSecuritiesCurrent`	$688.61M	USD	Point-in-time
Common stock, shares outstanding	`CommonStockSharesOutstanding`	95.14M	shares	Point-in-time
Accounts receivable, net of allowance of $2,429 in 2021 and $3,080 in 2020	`AccountsReceivableNetCurrent`	$78.56M	USD	Point-in-time
Accounts receivable, net of allowance of $2,429 in 2021 and $3,080 in 2020	`AccountsReceivableNetCurrent`	$122.07M	USD	Point-in-time
Inventory	`InventoryNet`	$20.03M	USD	Point-in-time
Inventory	`InventoryNet`	$26.91M	USD	Point-in-time
Prepaid expenses and other current assets, net	`PrepaidExpenseAndOtherAssetsCurrent`	$29.64M	USD	Point-in-time
Prepaid expenses and other current assets, net	`PrepaidExpenseAndOtherAssetsCurrent`	$26.61M	USD	Point-in-time
Total current assets	`AssetsCurrent`	$1.09B	USD	Point-in-time
Total current assets	`AssetsCurrent`	$862.66M	USD	Point-in-time
Property and equipment, net	`PropertyPlantAndEquipmentNet`	$33.35M	USD	Point-in-time
Property and equipment, net	`PropertyPlantAndEquipmentNet`	$65.52M	USD	Point-in-time
Operating lease right-of-use assets	`OperatingLeaseRightOfUseAsset`	$59.01M	USD	Point-in-time
Operating lease right-of-use assets	`OperatingLeaseRightOfUseAsset`	$21.40M	USD	Point-in-time
Other assets	`OtherAssetsNoncurrent`	$14.74M	USD	Point-in-time
Other assets	`OtherAssetsNoncurrent`	$18.82M	USD	Point-in-time
Total assets	`Assets`	$1.24B	USD	Point-in-time
Total assets	`Assets`	$932.15M	USD	Point-in-time
Accounts payable	`AccountsPayableCurrent`	$27.21M	USD	Point-in-time
Accounts payable	`AccountsPayableCurrent`	$8.10M	USD	Point-in-time
Accrued compensation	`EmployeeRelatedLiabilitiesCurrent`	$30.37M	USD	Point-in-time
Accrued compensation	`EmployeeRelatedLiabilitiesCurrent`	$40.94M	USD	Point-in-time
Other accrued liabilities	`OtherLiabilitiesCurrent`	$93.35M	USD	Point-in-time
Other accrued liabilities	`OtherLiabilitiesCurrent`	$60.41M	USD	Point-in-time
Deferred revenue, current portion	`ContractWithCustomerLiabilityCurrent`	$7.40M	USD	Point-in-time
Deferred revenue, current portion	`ContractWithCustomerLiabilityCurrent`	$50.12M	USD	Point-in-time
Short-term debt financing	`ShortTermBorrowings`	$50.05M	USD	Point-in-time
Short-term debt financing	`ShortTermBorrowings`	$50.05M	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$199.05M	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$218.96M	USD	Point-in-time
Long-term debt financing	`LongTermNotesAndLoans`	$280.39M	USD	Point-in-time
Long-term debt financing	`LongTermNotesAndLoans`	$202.49M	USD	Point-in-time
Deferred revenue, long-term portion	`ContractWithCustomerLiabilityNoncurrent`	$21.32M	USD	Point-in-time
Deferred revenue, long-term portion	`ContractWithCustomerLiabilityNoncurrent`	$22.80M	USD	Point-in-time
Operating lease liabilities, long-term portion	`OperatingLeaseLiabilityNoncurrent`	$21.25M	USD	Point-in-time
Operating lease liabilities, long-term portion	`OperatingLeaseLiabilityNoncurrent`	$61.04M	USD	Point-in-time
Other long-term liabilities	`OtherLiabilitiesNoncurrent`	$1.48M	USD	Point-in-time
Other long-term liabilities	`OtherLiabilitiesNoncurrent`	$320.00K	USD	Point-in-time
Total liabilities	`Liabilities`	$583.18M	USD	Point-in-time
Total liabilities	`Liabilities`	$445.92M	USD	Point-in-time
Commitments and contingencies (Note 8)	`CommitmentsAndContingencies`	-	USD	Point-in-time
Commitments and contingencies (Note 8)	`CommitmentsAndContingencies`	-	USD	Point-in-time
Common stock, $0.0001 par value: 750,000 shares authorized at December 31, 2021 and 2020, respectively; 95,140 and 86,223 shares issued and outstanding at December 31, 2021 and 2020, respectively	`CommonStockValue`	$9.00K	USD	Point-in-time
Common stock, $0.0001 par value: 750,000 shares authorized at December 31, 2021 and 2020, respectively; 95,140 and 86,223 shares issued and outstanding at December 31, 2021 and 2020, respectively	`CommonStockValue`	$10.00K	USD	Point-in-time
Additional paid in capital	`AdditionalPaidInCapitalCommonStock`	$1.41B	USD	Point-in-time
Additional paid in capital	`AdditionalPaidInCapitalCommonStock`	$2.05B	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-929.32M	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-1.39B	USD	Point-in-time
Accumulated other comprehensive gain (loss)	`AccumulatedOtherComprehensiveIncomeLossNetOfTax`	$4.26M	USD	Point-in-time
Accumulated other comprehensive gain (loss)	`AccumulatedOtherComprehensiveIncomeLossNetOfTax`	$-2.29M	USD	Point-in-time
Accumulated other comprehensive gain (loss)	`AccumulatedOtherComprehensiveIncomeLossNetOfTax`	$919.00K	USD	Point-in-time
Total stockholders' equity	`StockholdersEquity`	$278.71M	USD	Point-in-time
Total stockholders' equity	`StockholdersEquity`	$653.30M	USD	Point-in-time
Total stockholders' equity	`StockholdersEquity`	$486.24M	USD	Point-in-time
Total stockholders' equity	`StockholdersEquity`	$32.16M	USD	Point-in-time
Total liabilities and stockholders' equity	`LiabilitiesAndStockholdersEquity`	$1.24B	USD	Point-in-time
Total liabilities and stockholders' equity	`LiabilitiesAndStockholdersEquity`	$932.15M	USD	Point-in-time

Income Statement 50 line items

Line Item	Tag	Value	Unit	Period
Total revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$625.49M	USD	Annual
Total revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$391.00M	USD	Annual
Total revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$302.33M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$264.21M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$51.36M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$100.03M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$511.03M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$206.18M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$303.63M	USD	Annual
Gain from disposal of business	`GainLossOnSaleOfBusiness`	$14.39M	USD	Annual
Total cost and expenses	`CostsAndExpenses`	$607.28M	USD	Annual
Total cost and expenses	`CostsAndExpenses`	$1.09B	USD	Annual
Total cost and expenses	`CostsAndExpenses`	$418.62M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-116.29M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-468.17M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-216.28M	USD	Annual
Interest expense	`InterestExpense`	$15.08M	USD	Annual
Interest expense	`InterestExpense`	$8.30M	USD	Annual
Interest expense	`InterestExpense`	$10.69M	USD	Annual
Interest and other income, net	`InterestIncomeExpenseNonoperatingNet`	$4.15M	USD	Annual
Interest and other income, net	`InterestIncomeExpenseNonoperatingNet`	$7.56M	USD	Annual
Interest and other income, net	`InterestIncomeExpenseNonoperatingNet`	$5.38M	USD	Annual
Loss on debt extinguishment	`GainsLossesOnExtinguishmentOfDebt`	$-5.85M	USD	Annual
Loss before income taxes	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-471.10M	USD	Annual
Loss before income taxes	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-229.65M	USD	Annual
Loss before income taxes	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-122.83M	USD	Annual
Income tax expense	`IncomeTaxExpenseBenefit`	$618.00K	USD	Annual
Income tax expense	`IncomeTaxExpenseBenefit`	$98.00K	USD	Annual
Income tax expense	`IncomeTaxExpenseBenefit`	$2.00M	USD	Annual
Net loss	`NetIncomeLoss`	$-124.83M	USD	Annual
Net loss	`NetIncomeLoss`	$-471.72M	USD	Annual
Net loss	`NetIncomeLoss`	$-229.74M	USD	Annual
Unrealized gain (loss) on available-for-sale securities, net of tax	`OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$-6.55M	USD	Annual
Unrealized gain (loss) on available-for-sale securities, net of tax	`OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$1.47M	USD	Annual
Unrealized gain (loss) on available-for-sale securities, net of tax	`OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$3.34M	USD	Annual
Comprehensive loss	`ComprehensiveIncomeNetOfTax`	$-123.36M	USD	Annual
Comprehensive loss	`ComprehensiveIncomeNetOfTax`	$-478.26M	USD	Annual
Comprehensive loss	`ComprehensiveIncomeNetOfTax`	$-226.40M	USD	Annual
Basic (in dollars per share)	`EarningsPerShareBasic`	$-2.84	USD	Annual
Basic (in dollars per share)	`EarningsPerShareBasic`	$-1.79	USD	Annual
Basic (in dollars per share)	`EarningsPerShareBasic`	$-5.21	USD	Annual
Diluted (in dollars per share)	`EarningsPerShareDiluted`	$-1.79	USD	Annual
Diluted (in dollars per share)	`EarningsPerShareDiluted`	$-2.84	USD	Annual
Diluted (in dollars per share)	`EarningsPerShareDiluted`	$-5.21	USD	Annual
Basic (in shares)	`WeightedAverageNumberOfSharesOutstandingBasic`	69.56M	shares	Annual
Basic (in shares)	`WeightedAverageNumberOfSharesOutstandingBasic`	90.56M	shares	Annual
Basic (in shares)	`WeightedAverageNumberOfSharesOutstandingBasic`	81.01M	shares	Annual
Diluted (in shares)	`WeightedAverageNumberOfDilutedSharesOutstanding`	81.01M	shares	Annual
Diluted (in shares)	`WeightedAverageNumberOfDilutedSharesOutstanding`	90.56M	shares	Annual
Diluted (in shares)	`WeightedAverageNumberOfDilutedSharesOutstanding`	69.56M	shares	Annual

Cash Flow Statement 117 line items

Line Item	Tag	Value	Unit	Period
Net loss	`ProfitLoss`	$-471.72M	USD	Annual
Net loss	`ProfitLoss`	$-124.83M	USD	Annual
Net loss	`ProfitLoss`	$-229.74M	USD	Annual
Depreciation and amortization	`DepreciationDepletionAndAmortization`	$7.73M	USD	Annual
Depreciation and amortization	`DepreciationDepletionAndAmortization`	$8.61M	USD	Annual
Depreciation and amortization	`DepreciationDepletionAndAmortization`	$11.25M	USD	Annual
Expensed in-process research and development	`ResearchAndDevelopmentInProcess`	$35.60M	USD	Annual
Non-cash lease expense	`OperatingLeaseCost`	$7.75M	USD	Annual
Non-cash lease expense	`OperatingLeaseCost`	$10.93M	USD	Annual
Non-cash lease expense	`OperatingLeaseCost`	$7.83M	USD	Annual
Impairment of assets	`AssetImpairmentCharges`	$1.67M	USD	Annual
Impairment of assets	`AssetImpairmentCharges`	-	USD	Annual
Stock-based compensation	`ShareBasedCompensation`	$115.22M	USD	Annual
Stock-based compensation	`ShareBasedCompensation`	$28.62M	USD	Annual
Stock-based compensation	`ShareBasedCompensation`	$50.17M	USD	Annual
Inventory reserve adjustments	`InventoryReserveAdjustments`	$321.00K	USD	Annual
Inventory reserve adjustments	`InventoryReserveAdjustments`	$-163.00K	USD	Annual
Inventory reserve adjustments	`InventoryReserveAdjustments`	$628.00K	USD	Annual
Premium amortization and discount accretion on investment securities	`InvestmentIncomeAmortizationOfPremium`	$5.76M	USD	Annual
Premium amortization and discount accretion on investment securities	`InvestmentIncomeAmortizationOfPremium`	$7.81M	USD	Annual
Premium amortization and discount accretion on investment securities	`InvestmentIncomeAmortizationOfPremium`	$945.00K	USD	Annual
Loss on investments	`GainLossOnInvestments`	$16.00K	USD	Annual
Loss on investments	`GainLossOnInvestments`	$105.00K	USD	Annual
Loss on investments	`GainLossOnInvestments`	$46.00K	USD	Annual
Unrealized losses on investment securities	`MarketableSecuritiesUnrealizedGainLoss`	$11.00K	USD	Annual
Amortization of debt discount and issuance cost	`AmortizationOfDebtDiscountPremium`	$457.00K	USD	Annual
Amortization of debt discount and issuance cost	`AmortizationOfDebtDiscountPremium`	$1.23M	USD	Annual
Amortization of debt discount and issuance cost	`AmortizationOfDebtDiscountPremium`	$149.00K	USD	Annual
Other non-cash benefits (charges)	`OtherNonCashBenefitsCharges`	$94.00K	USD	Annual
Other non-cash benefits (charges)	`OtherNonCashBenefitsCharges`	$-149.00K	USD	Annual
Other non-cash benefits (charges)	`OtherNonCashBenefitsCharges`	$-51.00K	USD	Annual
Gain on disposal of business	`GainLossOnSaleOfBusiness`	$14.39M	USD	Annual
Provision for credit losses	`ProvisionForDoubtfulAccounts`	$1.14M	USD	Annual
Provision for credit losses	`ProvisionForDoubtfulAccounts`	$-156.00K	USD	Annual
Provision for credit losses	`ProvisionForDoubtfulAccounts`	$1.35M	USD	Annual
Loss on debt extinguishment	`GainsLossesOnExtinguishmentOfDebt`	$-5.85M	USD	Annual
Accretion of Convertible Note	`AccretionOfConvertibleNotesInterestExpenseDebt`	$7.05M	USD	Annual
Accounts receivable	`IncreaseDecreaseInAccountsReceivable`	$25.83M	USD	Annual
Accounts receivable	`IncreaseDecreaseInAccountsReceivable`	$43.35M	USD	Annual
Accounts receivable	`IncreaseDecreaseInAccountsReceivable`	$-2.42M	USD	Annual
Inventory	`IncreaseDecreaseInInventories`	$7.51M	USD	Annual
Inventory	`IncreaseDecreaseInInventories`	$7.47M	USD	Annual
Inventory	`IncreaseDecreaseInInventories`	$-917.00K	USD	Annual
Prepaid expenses and other current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$13.96M	USD	Annual
Prepaid expenses and other current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$10.54M	USD	Annual
Prepaid expenses and other current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$23.39M	USD	Annual
Other assets	`IncreaseDecreaseInOtherOperatingAssets`	$2.93M	USD	Annual
Other assets	`IncreaseDecreaseInOtherOperatingAssets`	$60.00K	USD	Annual
Other assets	`IncreaseDecreaseInOtherOperatingAssets`	$9.10M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$-6.26M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$19.22M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$-118.00K	USD	Annual
Accrued compensation	`IncreaseDecreaseInEmployeeRelatedLiabilities`	$10.57M	USD	Annual
Accrued compensation	`IncreaseDecreaseInEmployeeRelatedLiabilities`	$3.42M	USD	Annual
Accrued compensation	`IncreaseDecreaseInEmployeeRelatedLiabilities`	$14.28M	USD	Annual
Other accrued liabilities	`IncreaseDecreaseInOtherAccruedLiabilities`	$32.68M	USD	Annual
Other accrued liabilities	`IncreaseDecreaseInOtherAccruedLiabilities`	$8.61M	USD	Annual
Other accrued liabilities	`IncreaseDecreaseInOtherAccruedLiabilities`	$10.34M	USD	Annual
Deferred revenue	`IncreaseDecreaseInContractWithCustomerLiability`	$40.85M	USD	Annual
Deferred revenue	`IncreaseDecreaseInContractWithCustomerLiability`	$-44.21M	USD	Annual
Deferred revenue	`IncreaseDecreaseInContractWithCustomerLiability`	$-6.89M	USD	Annual
Other long-term liabilities	`IncreaseDecreaseInOtherNoncurrentLiabilities`	$310.00K	USD	Annual
Other long-term liabilities	`IncreaseDecreaseInOtherNoncurrentLiabilities`	$10.00K	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-63.44M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-335.24M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-182.51M	USD	Annual
Purchases of investments	`PaymentsToAcquireAvailableForSaleSecuritiesDebt`	$876.10M	USD	Annual
Purchases of investments	`PaymentsToAcquireAvailableForSaleSecuritiesDebt`	$685.24M	USD	Annual
Purchases of investments	`PaymentsToAcquireAvailableForSaleSecuritiesDebt`	$446.63M	USD	Annual
Proceeds from sale of investments	`ProceedsFromSaleOfAvailableForSaleSecuritiesDebt`	$30.07M	USD	Annual
Proceeds from sale of investments	`ProceedsFromSaleOfAvailableForSaleSecuritiesDebt`	$187.58M	USD	Annual
Proceeds from sale of investments	`ProceedsFromSaleOfAvailableForSaleSecuritiesDebt`	$1.67M	USD	Annual
Proceeds from maturity of investments	`ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities`	$173.90M	USD	Annual
Proceeds from maturity of investments	`ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities`	$343.31M	USD	Annual
Proceeds from maturity of investments	`ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities`	$532.91M	USD	Annual
Net proceeds from disposal of business	`ProceedsFromDivestitureOfBusinesses`	$9.68M	USD	Annual
Purchases of property and equipment, net	`PaymentsToAcquirePropertyPlantAndEquipment`	$4.97M	USD	Annual
Purchases of property and equipment, net	`PaymentsToAcquirePropertyPlantAndEquipment`	$41.03M	USD	Annual
Purchases of property and equipment, net	`PaymentsToAcquirePropertyPlantAndEquipment`	$19.60M	USD	Annual
Cash paid for acquisition of an asset	`PaymentsToAcquireBusinessesNetOfCashAcquired`	$8.56M	USD	Annual
Net cash used in investing activities	`NetCashProvidedByUsedInInvestingActivities`	$-266.35M	USD	Annual
Net cash used in investing activities	`NetCashProvidedByUsedInInvestingActivities`	$-331.46M	USD	Annual
Net cash used in investing activities	`NetCashProvidedByUsedInInvestingActivities`	$-205.19M	USD	Annual
Proceeds from exercise of stock options	`ProceedsFromStockOptionsExercised`	$11.82M	USD	Annual
Proceeds from exercise of stock options	`ProceedsFromStockOptionsExercised`	$23.52M	USD	Annual
Proceeds from exercise of stock options	`ProceedsFromStockOptionsExercised`	$13.04M	USD	Annual
Proceeds from issuance of common stock under employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans`	$13.55M	USD	Annual
Proceeds from issuance of common stock under employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans`	$4.32M	USD	Annual
Proceeds from issuance of common stock under employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans`	$7.11M	USD	Annual
Proceeds from Convertible Note, net of issuance costs	`ProceedsFromConvertibleDebt`	$278.32M	USD	Annual
Loan payment	`RepaymentsOfConvertibleDebt`	$78.76M	USD	Annual
Proceeds from public offering, net of issuance costs	`ProceedsFromIssuanceOfCommonStockNet`	$270.65M	USD	Annual
Proceeds from public offering, net of issuance costs	`ProceedsFromIssuanceOfCommonStockNet`	$550.82M	USD	Annual
Proceeds from public offering, net of issuance costs	`ProceedsFromIssuanceOfCommonStockNet`	$323.41M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$340.77M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$576.19M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$500.85M	USD	Annual
Net increase (decrease) in cash equivalents and restricted cash	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect`	$-13.13M	USD	Annual
Net increase (decrease) in cash equivalents and restricted cash	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect`	$35.76M	USD	Annual
Net increase (decrease) in cash equivalents and restricted cash	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect`	$10.98M	USD	Annual
Beginning - cash equivalents & restricted cash	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$51.00M	USD	Point-in-time
Beginning - cash equivalents & restricted cash	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$61.98M	USD	Point-in-time
Beginning - cash equivalents & restricted cash	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$84.61M	USD	Point-in-time
Beginning - cash equivalents & restricted cash	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$48.85M	USD	Point-in-time
Ending - cash equivalents and restricted cash	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$51.00M	USD	Point-in-time
Ending - cash equivalents and restricted cash	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$61.98M	USD	Point-in-time
Ending - cash equivalents and restricted cash	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$84.61M	USD	Point-in-time
Ending - cash equivalents and restricted cash	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$48.85M	USD	Point-in-time
Cash paid for income taxes	`IncomeTaxesPaidNet`	$2.15M	USD	Annual
Cash paid for income taxes	`IncomeTaxesPaidNet`	$283.00K	USD	Annual
Cash paid for income taxes	`IncomeTaxesPaidNet`	$67.00K	USD	Annual
Cash paid for interest	`InterestPaidNet`	$3.30M	USD	Annual
Cash paid for interest	`InterestPaidNet`	$12.46M	USD	Annual
Cash paid for interest	`InterestPaidNet`	$7.08M	USD	Annual
Purchases of property and equipment in accounts payable and accruals	`CapitalExpendituresIncurredButNotYetPaid`	$3.71M	USD	Annual
Purchases of property and equipment in accounts payable and accruals	`CapitalExpendituresIncurredButNotYetPaid`	$5.17M	USD	Annual
Purchases of property and equipment in accounts payable and accruals	`CapitalExpendituresIncurredButNotYetPaid`	$2.78M	USD	Annual

Stockholders Equity 43 line items

Line Item	Tag	Value	Unit	Period
Balance	`StockholdersEquity`	$278.71M	USD	Point-in-time
Balance	`StockholdersEquity`	$653.30M	USD	Point-in-time
Balance	`StockholdersEquity`	$486.24M	USD	Point-in-time
Balance	`StockholdersEquity`	$32.16M	USD	Point-in-time
Balance (in shares)	`CommonStockSharesIssued`	5.71M	shares	Point-in-time
Balance (in shares)	`CommonStockSharesIssued`	86.22M	shares	Point-in-time
Balance (in shares)	`CommonStockSharesIssued`	95.14M	shares	Point-in-time
Balance (in shares)	`CommonStockSharesIssued`	4.79M	shares	Point-in-time
Balance (in shares)	`CommonStockSharesIssued`	5.26M	shares	Point-in-time
Balance (in shares)	`CommonStockSharesIssued`	5.17M	shares	Point-in-time
Issuance of common stock upon exercise of stock options	`StockIssuedDuringPeriodValueStockOptionsExercised`	$23.52M	USD	Annual
Issuance of common stock upon exercise of stock options	`StockIssuedDuringPeriodValueStockOptionsExercised`	$11.82M	USD	Annual
Issuance of common stock upon exercise of stock options	`StockIssuedDuringPeriodValueStockOptionsExercised`	$13.04M	USD	Annual
Issuance of common stock under employee stock purchase plan	`StockIssuedDuringPeriodValueEmployeeStockPurchasePlan`	$7.11M	USD	Annual
Issuance of common stock under employee stock purchase plan	`StockIssuedDuringPeriodValueEmployeeStockPurchasePlan`	$13.55M	USD	Annual
Issuance of common stock under employee stock purchase plan	`StockIssuedDuringPeriodValueEmployeeStockPurchasePlan`	$4.32M	USD	Annual
Issuance of common stock to Orbimed	`StockIssuedDuringPeriodValueIssuedForServices`	$507.00K	USD	Annual
Stock based compensation	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$50.17M	USD	Annual
Stock based compensation	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$115.22M	USD	Annual
Stock based compensation	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$28.62M	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax`	$-6.55M	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax`	$3.34M	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax`	$1.47M	USD	Annual
Cumulative-effect adjustment upon adoption	`CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoptionDuration`	$-76.68M	USD	Annual
Cumulative-effect adjustment upon adoption	`CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoptionDuration`	$-404.00K	USD	Annual
Equity component of Convertible Notes, net	`AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt`	$82.87M	USD	Annual
Issuance/Sale of common stock for offering, net	`StockIssuedDuringPeriodValueNewIssues`	$550.82M	USD	Annual
Issuance/Sale of common stock for offering, net	`StockIssuedDuringPeriodValueNewIssues`	$270.65M	USD	Annual
Issuance/Sale of common stock for offering, net	`StockIssuedDuringPeriodValueNewIssues`	$323.41M	USD	Annual
Issuance of common stock for IPR&D acquisition	`StockIssuedDuringPeriodValueAcquisitions`	$30.60M	USD	Annual
Net loss	`NetIncomeLoss`	$-124.83M	USD	Annual
Net loss	`NetIncomeLoss`	$-471.72M	USD	Annual
Net loss	`NetIncomeLoss`	$-229.74M	USD	Annual
Balance	`StockholdersEquity`	$278.71M	USD	Point-in-time
Balance	`StockholdersEquity`	$653.30M	USD	Point-in-time
Balance	`StockholdersEquity`	$486.24M	USD	Point-in-time
Balance	`StockholdersEquity`	$32.16M	USD	Point-in-time
Balance (in shares)	`CommonStockSharesIssued`	5.71M	shares	Point-in-time
Balance (in shares)	`CommonStockSharesIssued`	86.22M	shares	Point-in-time
Balance (in shares)	`CommonStockSharesIssued`	95.14M	shares	Point-in-time
Balance (in shares)	`CommonStockSharesIssued`	4.79M	shares	Point-in-time
Balance (in shares)	`CommonStockSharesIssued`	5.26M	shares	Point-in-time
Balance (in shares)	`CommonStockSharesIssued`	5.17M	shares	Point-in-time

Data is extracted from SEC EDGAR XBRL filings. Values shown are as reported in the filing.